Intravenous immunoglobulin preparations have no direct effect on B cell proliferation and immunoglobulin production

Immunoglobulin Production Inhibitory Effects on B Cell Proliferation and Anthrax Lethal Toxin Has Direct and Potent

Uses of intravenous immunoglobulin

Adjuvant high dose IVIgs are being used increasingly in a range of immune-mediated and auto-immune diseases. Although numerous immunomodulatory mechanisms have been suggested, the exact mechanisms of action are poorly understood. The efficacy of IVIg in certain diseases has been proven in clinical trials, in so far as IVIg is approved as the therapy of choice for Kawasaki syndrome and idiopathi...

Cell Proliferation and Immunoglobulin Production in Human Hematopoietic Cell Culture

The nutritional requirements generally satisfied by serum in established cultures of human hematopoietic cells were studied in spinner culture. The optimum concentration of fetal calf serum for cell proliferation in medium RPMI #1640 appeared to be 20%, and the minimum to be 2%. In the logarithmic phase of cell growth, there was an exponential increase of protein in the cells and a correspondin...

The Significance of B-cell Subsets in Patients with Unclassified Hypogammaglobulinemia and Association with Intravenous Immunoglobulin Replacement Requirement

Background: Patients with unclassified hypogammaglobulinemia (UCH) constitute a diagnostic and therapeutic dilemma, because information concerning the clinical and immunological characteristics of these patients is insufficient. Objective: To evaluate B-cell subsets in cases with UCH and common variable immunodeficiency (CVID) and their association with treatment requirement in UCH patients. Me...

Requirements for safety and quality of intravenous immunoglobulin G preparations.

The increasing use of intravenous immunoglobulin-G preparations (IVIg) calls for evaluation of the requirements for quality and freedom from infection. The WHO Requirements dating from 1982 have been surpassed by the majority of IVIg preparations. Three methods are used for ensuring safety from infection: the restrictive choice of donor, the precise introductory screening of every individual bl...